Considering the recent regulatory requirements, the overall importance of in vitro release\ntesting (IVRT) methods regarding topical product development is undeniable, especially when\naddressing particulate systems. For each IVRT study, several hundreds of samples are generated.\nTherefore, developing rapid reversed-phase high-performance liquid chromatography (RP-HPLC)\nmethods, able to provide a real-time drug analysis of IVRT samples, is a priority. In this study,\neight topical complex drug products exhibiting distinct physicochemical profiles were considered.\nRP-HPLC methods were developed and fully validated. Chromatographic separations were achieved.............
Loading....